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Cancer Immunotherapy Breakthrough

Tel Aviv University researchers discovered a mechanism that prevents the immune system from attacking tumors, potentially leading to more effective immunotherapies.

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English

Israel

HealthCancerResearchTreatmentMedicineImmunology

Tel Aviv UniversityNature Communications

Prof. Carmit LevyProf. Yaron CarmiAvishai Maliah

What are the next steps for the research team?: The research team is now working to translate their findings into a potential treatment for human cancer patients, offering a new treatment option for those with limited treatment responses.
How did the researchers initially stumble upon this discovery?: The discovery was accidental, stemming from research on UV radiation's effects on the immune system, and showed that Ly6a is overexpressed in melanoma and colon cancer.
What is the main discovery of the Tel Aviv University researchers?: Researchers at Tel Aviv University discovered that the protein Ly6a, overexpressed in tumors, acts as a brake on T cells, preventing the immune system from attacking cancer cells.
What were the results of the treatment with antibodies targeting Ly6a?: Antibodies targeting Ly6a led to significant tumor shrinkage in animal models, even in cancers resistant to other immunotherapies, suggesting a potential new treatment.
What is the potential significance of this research for cancer treatment?: The breakthrough could significantly improve immunotherapy, as about 50% of cancer patients don't respond to current treatments; this research offers a potential solution for them.

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