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Carl June and the Future of CAR-T Therapy

Immunologist Carl June receives the Juan Abarca Prize for his revolutionary CAR-T cancer therapy, and discusses its future potential.

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HealthCancerResearchTreatmentMedicineImmunology

University Of PennsylvaniaPerelman School Of MedicineParker Institute For Cancer Immunotherapy

Carl H. JuneCynthia June

Explain the basic mechanism of CAR-T therapy.: CAR-T therapy involves extracting a patient's T cells, modifying them to target cancer cells, and then infusing them back into the patient. This precision approach has shown remarkable success in treating various blood cancers.
What are some of the current and future applications of CAR-T therapy?: The success of CAR-T therapy in hematological cancers has spurred its application to other diseases such as lupus. June is optimistic about future applications, particularly in treating difficult-to-treat solid tumors.
Who is Carl June and what is his significance in the field of medicine?: Carl June, the recipient of the 2024 Juan Abarca International Prize for Medical Sciences, is known as the "father of CAR-T therapy". His revolutionary treatment has significantly improved outcomes for many blood cancers.
How did Carl June's research on HIV contribute to his work on cancer treatment?: June's work on CAR-T therapy began in the 1990s with research on HIV. His wife's ovarian cancer diagnosis shifted his focus to cancer research, leading him to adapt his knowledge of immune system stimulation to develop CAR-T.
What is Carl June's current research focus, and what are his hopes for the future of CAR-T therapy?: While CAR-T has shown impressive results, June's current focus is on extending its use to solid tumors like glioblastoma and pancreatic cancer. He remains hopeful that this will be achievable in the future.

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