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ecDNA: A Driver of Aggressive Cancers
A new study reveals that tiny circles of extrachromosomal DNA (ecDNA) are a major driver of aggressive cancers. Researchers are exploring ways to target ecDNA as a novel cancer treatment strategy.
Spanish
Spain
HealthCancerResearchTreatmentGeneticsDna
Instituto Francis CrickStanford UniversityCancer Research UkInstituto Nacional Del Cáncer De Ee UuCentro Nacional De Investigaciones Oncológicas
Oriol PichChris BaileyPaul MischelCharles SwantonJuan Méndez
- What is ecDNA and what role does it play in cancer?
- Tiny circles of extrachromosomal DNA (ecDNA) have been found in over half of cancer patients. This ecDNA is associated with aggressive cancers like HER2+ breast cancer and glioblastoma, and its presence correlates with poorer patient survival.
- What is the history of ecDNA research and its significance?
- ecDNA was first discovered in 1965 but was considered insignificant until 2017. Recent research reveals that it acts as a driver of cancer progression by increasing the number of copies of cancer-related genes.
- Is ecDNA the sole cause of cancer or is its role more complex?
- While ecDNA's role in cancer initiation is not fully understood, studies suggest it is not the sole cause but a significant contributor to cancer progression and aggressiveness.
- What are the potential treatment strategies for ecDNA-driven cancers?
- The international consortium eDyNAmiC is researching ecDNA and has found that blocking the CHK1 protein can lead to the death of tumor cells with ecDNA. They are currently testing an experimental treatment in humans.
- What is the future outlook of ecDNA research and its implications for cancer treatment?
- Researchers are optimistic about targeting ecDNA as a cancer treatment strategy. Further research is needed to fully understand its role in cancer development and to refine treatment strategies.