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Mixing Antidepressants with Alcohol and Other Substances

This article discusses the risks of mixing alcohol, weed, and over-the-counter medications with antidepressants, offering advice for college students.

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English

United States

HealthMental HealthAlcoholDrugsCollegeMedication

CnnUs Centers For Disease Control And PreventionFda

Jill Grimes

What about using weed?: Combining weed with antidepressants may lead to increased anxiety, paranoia, or other adverse effects due to interactions with liver enzymes and inconsistent THC levels. It is best to avoid cannabis while taking antidepressants.
Are any over-the-counter meds off-limits if I get sick?: Many over-the-counter cold medications contain dextromethorphan, which can interact with antidepressants and increase the risk of serotonin syndrome. Consult your doctor or pharmacist before combining medications.
What is the worst thing that will happen if I drink too much?: While an occasional drink may pose a low risk for some on SSRIs or SNRIs, it's best to avoid alcohol completely while taking antidepressants. The risk is significantly higher with MAOIs, where alcohol can cause a potentially fatal blood pressure spike.
Is it safe to drink alcohol while taking antidepressant medications?: Mixing alcohol with antidepressants can enhance the sedative effects, impair judgment, and increase the risk of seizures. The safest course is to avoid alcohol entirely while on antidepressants.
What will happen if I skip a dose of my medicine so I can drink at a party?: Skipping antidepressant doses to drink is dangerous, as it doesn't reduce the interaction risk and may cause withdrawal symptoms such as headaches, nausea, and increased anxiety. It's crucial to maintain consistent medication.

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