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Unraveling the Wet Dog Shake: Genes, Receptors, and Neural Pathways
Scientists identify the specific receptors and genes responsible for the "wet dog shake" reflex, highlighting the role of C-LTMRs and the Piezo2 gene. The findings shed light on the complex interplay between sensory input and motor output.
Dutch
Netherlands
HealthAnimal BehaviorSensory ReceptorsGene FunctionNeural PathwaysReflex Arc
Science
- How do the findings relate to the sensation of touch in humans?
- While human C-receptors are involved in pleasant touches, the study suggests that mouse C-LTMRs might be more associated with a ticklish sensation rather than a feeling of being caressed.
- What is the role of C-LTMRs and vellus hair in the wet dog shake?
- C-LTMRs, located in hair follicles, respond strongly to slow touches and are connected to the vellus hair, the soft undercoat. Stimulation of these receptors may trigger the shake to remove unwanted substances.
- What is the "wet dog shake" and which animals exhibit this behavior?
- The wet dog shake is a reflex behavior observed in many hairy mammals, including dogs, bears, lions, and mice, used to dry or clean themselves.
- What are the essential genes and receptors involved in the wet dog shake?
- The Piezo2 gene and C-LTMRs (low-threshold mechanoreceptors) are crucial for the wet dog shake. Inactivation of Piezo2 eliminates the shake, while disabling C-LTMRs reduces it by 50%.
- Describe the neural pathway involved in transmitting and processing signals related to the wet dog shake.
- Signals from C-LTMRs are transmitted to the brain via specific nerve cells in the spinal cord, then processed in the parabrachial nucleus, an area associated with pain, temperature, and touch signals.