Tag #Genetic Mutation

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cnnespanol.cnn.com

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Feb 9, 10:11

Nevada Dairy Cattle Infected with Mutated Avian Flu Variant

A new H5N1 avian flu variant (D1.1) has infected dairy cattle in Nevada, causing the state's first human infection in a dairy worker exhibiting conjunctivitis; this variant has a genetic change facilitating easier replication in mammals, although the CDC states the overall public risk remains low.

Nevada Dairy Cattle Infected with Mutated Avian Flu Variant

A new H5N1 avian flu variant (D1.1) has infected dairy cattle in Nevada, causing the state's first human infection in a dairy worker exhibiting conjunctivitis; this variant has a genetic change facilitating easier replication in mammals, although the CDC states the overall public risk remains low.

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How did the H5N1 D1.1 variant likely transmit to the Nevada cattle, and what factors might have contributed to this event?

The D1.1 variant, initially found in wild birds, is now the dominant H5N1 strain in North America. Two severe human infections, including one fatality, have been linked to D1.1, raising concerns about its potential for human-to-human transmission. The mutation facilitating mammalian replication is unique to this variant.

nrc.nl

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Dec 12, 01:09

Single Mutation Increases Avian Flu Pandemic Risk

A single genetic mutation allows avian flu from US dairy cows to bind to human airway cells, increasing pandemic risk; 35 Americans infected, but no human-to-human transmission yet.

Single Mutation Increases Avian Flu Pandemic Risk

A single genetic mutation allows avian flu from US dairy cows to bind to human airway cells, increasing pandemic risk; 35 Americans infected, but no human-to-human transmission yet.

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What measures should be implemented to mitigate the risk of a pandemic resulting from this easily mutable avian flu virus?

The findings underscore the urgent need for enhanced surveillance and preparedness. Though human-to-human transmission hasn't been observed yet, this single mutation drastically increases the likelihood of a pandemic. Further mutations could render the virus highly contagious among humans.

abcnews.go.com

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Jan 16, 19:09

Huntington's Disease: CAG Repeat Expansion Identified as Key Disease Mechanism

New research shows that the Huntington's disease mutation, involving a repeated DNA sequence (CAG), expands over time, remaining harmless until it surpasses 150 repeats, triggering toxic protein production and neuronal death; this discovery could lead to new treatment strategies.

Huntington's Disease: CAG Repeat Expansion Identified as Key Disease Mechanism

New research shows that the Huntington's disease mutation, involving a repeated DNA sequence (CAG), expands over time, remaining harmless until it surpasses 150 repeats, triggering toxic protein production and neuronal death; this discovery could lead to new treatment strategies.

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What is the key mechanism by which the Huntington's disease mutation causes neuronal damage, and what is its clinical significance?

Huntington's disease, a fatal hereditary disorder, is caused by a genetic mutation where a DNA sequence (CAG) repeats at least 40 times. This mutation remains harmless for decades but expands over time, eventually exceeding a threshold of about 150 repeats, leading to toxic protein production and neuronal death.

Showing 13 to 15 of 15 results