Tag #Neurodegenerative Disease

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elpais.com

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Jun 25, 07:17

Tetraneuron's Novel Gene Therapy Targets Alzheimer's Disease by Restoring Neuronal Function

Tetraneuron, based on research from the Cajal Institute in Madrid, is developing a gene therapy for moderate-to-severe Alzheimer's disease by targeting the transcription factor E2F4, showing promising results in animal models and aiming for human trials in 2026.

Tetraneuron's Novel Gene Therapy Targets Alzheimer's Disease by Restoring Neuronal Function

Tetraneuron, based on research from the Cajal Institute in Madrid, is developing a gene therapy for moderate-to-severe Alzheimer's disease by targeting the transcription factor E2F4, showing promising results in animal models and aiming for human trials in 2026.

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What are the main challenges Tetraneuron faces in transitioning its gene therapy from preclinical studies to human trials?

Unlike existing treatments focusing on amyloid plaques, Tetraneuron's gene therapy seeks to reverse neuronal damage by restoring E2F4 function. Positive results in mice show potential for reversing Alzheimer's, restoring synaptic plasticity crucial for memory formation, a mechanism not addressed by current therapies. This offers a fundamentally different approach to treating the disease.

dailymail.co.uk

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Jun 10, 16:12

Gut Microbiome Imbalance Linked to Increased Parkinson's Risk

A King's College London study found that people with Parkinson's disease have a less diverse gut microbiome and higher levels of harmful bacteria than healthy controls, suggesting that a diet low in ultra-processed foods could reduce the risk of developing Parkinson's.

Gut Microbiome Imbalance Linked to Increased Parkinson's Risk

A King's College London study found that people with Parkinson's disease have a less diverse gut microbiome and higher levels of harmful bacteria than healthy controls, suggesting that a diet low in ultra-processed foods could reduce the risk of developing Parkinson's.

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What is the primary link identified between diet and the development of Parkinson's disease?

A new study suggests a link between regular consumption of ultra-processed foods and an increased risk of Parkinson's disease. The research indicates that these foods harm gut bacteria, potentially triggering inflammation and brain damage. This is supported by the observation that Parkinson's patients had less diverse gut microbiomes and higher levels of harmful bacteria.

dailymail.co.uk

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May 8, 01:17

High Ultra-Processed Food Consumption Linked to Increased Parkinson's Risk

A study of 42,853 individuals over 26 years revealed that those consuming 11 or more daily servings of ultra-processed foods had a 2.5 times greater risk of early Parkinson's symptoms (sleep issues, fatigue, etc.) than those consuming three or fewer; even three or fewer servings increased risk by up...

High Ultra-Processed Food Consumption Linked to Increased Parkinson's Risk

A study of 42,853 individuals over 26 years revealed that those consuming 11 or more daily servings of ultra-processed foods had a 2.5 times greater risk of early Parkinson's symptoms (sleep issues, fatigue, etc.) than those consuming three or fewer; even three or fewer servings increased risk by up...

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What is the direct impact of high ultra-processed food consumption on the likelihood of developing early Parkinson's symptoms?

A study by Chinese scientists found a strong correlation between high ultra-processed food consumption and early Parkinson's symptoms. Individuals consuming 11 or more servings daily showed a 2.5 times increased risk of symptoms like sleep issues and fatigue compared to those eating three or fewer servings. Even lower consumption increased the risk by up to 60 percent, depending on the specific food.

forbes.com

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Apr 23, 01:14

Parkinson's Disease: Impact, Causes, and Future Directions

Parkinson's disease, a progressive neurodegenerative disorder affecting over one million Americans, is marked by a loss of dopamine-producing nerve cells causing motor and non-motor symptoms; while genetic factors play a minor role, environmental toxins are strongly implicated, and men are 1.5 times...

Parkinson's Disease: Impact, Causes, and Future Directions

Parkinson's disease, a progressive neurodegenerative disorder affecting over one million Americans, is marked by a loss of dopamine-producing nerve cells causing motor and non-motor symptoms; while genetic factors play a minor role, environmental toxins are strongly implicated, and men are 1.5 times...

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What are the known and suspected causes of Parkinson's disease, and how do these factors contribute to its prevalence and impact?

Parkinson's disease, the second most common neurodegenerative disease after Alzheimer's, is characterized by the loss of dopamine-producing nerve cells. While genetic factors play a role (less than 20 percent of cases), environmental toxins like pesticides and TCE are strongly linked to its onset, suggesting a multifactorial etiology. Gender also plays a significant role, with men being 1.5 times more likely to develop the disease than women.

dw.com

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Apr 16, 04:09

EU Approves Lecanemab for Early-Stage Alzheimer's; Strict Criteria Apply

The European Commission approved Lecanemab, a new Alzheimer's drug targeting amyloid plaques, for patients with minimal cognitive impairment and low ApoE4 gene copies; it offers a five-month delay in cognitive decline but is restricted due to potential side effects.

EU Approves Lecanemab for Early-Stage Alzheimer's; Strict Criteria Apply

The European Commission approved Lecanemab, a new Alzheimer's drug targeting amyloid plaques, for patients with minimal cognitive impairment and low ApoE4 gene copies; it offers a five-month delay in cognitive decline but is restricted due to potential side effects.

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What is the significance of the European Commission's approval of Lecanemab for Alzheimer's treatment?

The European Commission approved Lecanemab, a monoclonal antibody, to treat early-stage Alzheimer's. Unlike previous treatments, it targets the disease itself by reducing amyloid plaques, not just symptoms. However, its use is restricted to patients with minimal cognitive impairment and only one or zero copies of the ApoE4 gene to minimize risks of serious side effects.

elmundo.es

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Mar 31, 19:14

New Biomarker Predicts Alzheimer's Cognitive Decline

Researchers at Stanford University have discovered a new biomarker—a ratio of two synaptic proteins (YWHAG and NPTX2)—that accurately predicts cognitive decline in Alzheimer's disease, potentially improving early diagnosis and treatment selection.

New Biomarker Predicts Alzheimer's Cognitive Decline

Researchers at Stanford University have discovered a new biomarker—a ratio of two synaptic proteins (YWHAG and NPTX2)—that accurately predicts cognitive decline in Alzheimer's disease, potentially improving early diagnosis and treatment selection.

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How did the researchers identify this biomarker, and what factors were considered in their analysis?

The research, involving nearly 3,400 individuals across six cohorts, utilized machine learning to analyze proteomic data from cerebrospinal fluid and brain tissue. A higher ratio of YWHAG to NPTX2 correlated with increased dementia risk, regardless of amyloid or tau levels. This finding addresses a critical gap in current diagnostic tools, which lack predictive power.

dailymail.co.uk

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Jun 11, 04:11

Sensory Changes: Early Warning Signs of Dementia

Experts warn that changes in sight, hearing, taste, touch, and balance can be early signs of dementia, striking years before memory problems, offering hope for earlier diagnosis and intervention; studies show sensory changes are often overlooked, highlighting the need for their inclusion in standard...

Sensory Changes: Early Warning Signs of Dementia

Experts warn that changes in sight, hearing, taste, touch, and balance can be early signs of dementia, striking years before memory problems, offering hope for earlier diagnosis and intervention; studies show sensory changes are often overlooked, highlighting the need for their inclusion in standard...

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What are the early warning signs of dementia that can occur years before the commonly known symptoms?

Changes in senses like sight, hearing, taste, touch, and balance can appear years before typical dementia symptoms (memory loss, language issues, mood changes). These sensory changes may offer an earlier diagnosis window, potentially improving treatment effectiveness and patient support. This is supported by the experiences of many patients who reported such changes years prior to diagnosis.

repubblica.it

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May 9, 22:11

ALS: Symptoms, Causes, and Emerging Treatments

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease affecting motor neurons, causing muscle weakness, speech/swallowing difficulties, and eventually paralysis; it affects 1–3 per 100,000 globally, with Riluzole offering some treatment, while research focuses on immunotherapies.

ALS: Symptoms, Causes, and Emerging Treatments

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease affecting motor neurons, causing muscle weakness, speech/swallowing difficulties, and eventually paralysis; it affects 1–3 per 100,000 globally, with Riluzole offering some treatment, while research focuses on immunotherapies.

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What are the most prevalent initial symptoms of ALS, and what is their global health significance?

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disease affecting motor neurons. Initial symptoms, varying widely among individuals, often include muscle weakness, twitching, cramps, or difficulties with speech and swallowing. Delayed diagnosis is common due to the non-specific nature of early symptoms.

cnn.com

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May 8, 01:17

High Ultra-Processed Food Intake Linked to Increased Parkinson's Disease Risk

A study of nearly 43,000 participants found that consuming 11 or more servings of ultra-processed foods daily is associated with a 2.5 times greater likelihood of experiencing multiple early-stage Parkinson's symptoms compared to those eating only three servings; the findings suggest potential preve...

High Ultra-Processed Food Intake Linked to Increased Parkinson's Disease Risk

A study of nearly 43,000 participants found that consuming 11 or more servings of ultra-processed foods daily is associated with a 2.5 times greater likelihood of experiencing multiple early-stage Parkinson's symptoms compared to those eating only three servings; the findings suggest potential preve...

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How does this study's methodology and the type of data collected contribute to its findings regarding the link between ultra-processed foods and Parkinson's disease?

This research, involving nearly 43,000 participants over 26 years, links high ultra-processed food consumption to an increased risk of prodromal Parkinson's symptoms. The study points towards potential mechanisms like reduced micronutrients, increased inflammation, and gut microbiome disruption as contributing factors. These findings highlight the dietary component's role in neurodegenerative disease.

bbc.com

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Apr 16, 10:08

Northern Scotland's High Huntington's Disease Rate Prompts Call for Action

A new study shows Northern Scotland has a Huntington's disease rate of 14.5 per 100,000 people—over five times the global average—with over 160 adults in the region genetically predisposed but untested, prompting calls for improved care planning.

Northern Scotland's High Huntington's Disease Rate Prompts Call for Action

A new study shows Northern Scotland has a Huntington's disease rate of 14.5 per 100,000 people—over five times the global average—with over 160 adults in the region genetically predisposed but untested, prompting calls for improved care planning.

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How does this study's methodology differ from previous research, and what additional insights does it provide regarding the scope of the problem?

The study's use of family tree records, unlike previous statistical models, provides a more precise count of those at risk. This precise data is crucial for planning healthcare services and future treatments. The high rate necessitates immediate action for resource allocation and care planning.

repubblica.it

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Apr 9, 10:13

Saliva Test Distinguishes Lewy Body Dementia from Alzheimer's and Parkinson's

Researchers at Roma Tre University discovered two salivary biomarkers—alpha-synuclein and phosphorylated tau protein—that distinguish Lewy body dementia from Alzheimer's and Parkinson's, impacting 200,000 undiagnosed Italians.

Saliva Test Distinguishes Lewy Body Dementia from Alzheimer's and Parkinson's

Researchers at Roma Tre University discovered two salivary biomarkers—alpha-synuclein and phosphorylated tau protein—that distinguish Lewy body dementia from Alzheimer's and Parkinson's, impacting 200,000 undiagnosed Italians.

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What are the key findings of the Roma Tre University study on Lewy body dementia, and how will this impact diagnosis and treatment?

Researchers at Roma Tre University discovered two salivary biomarkers—alpha-synuclein and phosphorylated tau protein—that can distinguish Lewy body dementia (LBD) from Alzheimer's and Parkinson's diseases. This discovery simplifies LBD diagnosis, enabling earlier and more effective treatment for the estimated 200,000 undiagnosed LBD sufferers in Italy.

arabic.euronews.com

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Mar 22, 10:09

Eight-Year Gantenerumab Treatment Shows Promise in Delaying Alzheimer's Onset

A small clinical trial of 22 genetically predisposed individuals showed that eight years of treatment with gantenerumab reduced their risk of developing Alzheimer's symptoms by half; however, the drug was later discontinued due to inefficacy in larger trials.

Eight-Year Gantenerumab Treatment Shows Promise in Delaying Alzheimer's Onset

A small clinical trial of 22 genetically predisposed individuals showed that eight years of treatment with gantenerumab reduced their risk of developing Alzheimer's symptoms by half; however, the drug was later discontinued due to inefficacy in larger trials.

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What are the limitations of this study, and what further research is needed to validate these findings?

The study, published in The Lancet Neurology, indicates that preventative treatment with anti-amyloid antibodies may need to be administered for several years before symptoms appear to be effective. While promising, the results are considered preliminary due to the small sample size and the fact that gantenerumab is less effective than other available anti-amyloid treatments.

Showing 1 to 12 of 23 results