Tag #Posttranslational Modifications

How did the researchers use evolutionary biology and comparative genomics to identify these longevity-associated protein modifications, and what were the limitations of their approach?

The study analyzed protein sequences across diverse mammal species, revealing consistent PTMs in long-lived animals. These modifications, particularly acetylation, are implicated in cellular processes and disease resistance. The findings suggest that manipulating these naturally occurring mechanisms could slow aging and combat age-related diseases.