Tag #Rna

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dw.com

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Sep 2, 22:21

Scientists Show How RNA and Amino Acids Could Have Combined to Create Life 4 Billion Years Ago

A new study published in Nature demonstrates that RNA and amino acids, essential ingredients for life, could have combined on their own around 4 billion years ago in conditions similar to early Earth, specifically in ponds or lakes, marking a key step in understanding the origin of protein synthesis...

Scientists Show How RNA and Amino Acids Could Have Combined to Create Life 4 Billion Years Ago

A new study published in Nature demonstrates that RNA and amino acids, essential ingredients for life, could have combined on their own around 4 billion years ago in conditions similar to early Earth, specifically in ponds or lakes, marking a key step in understanding the origin of protein synthesis...

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How did the scientists achieve this result, and what role did thioesters play?

The scientists successfully combined amino acids with RNA using thioesters, high-energy compounds known to be present in early biochemical processes. These thioesters were formed by reacting amino acids with pantetheine, a sulfur-containing compound. Unlike previous attempts, this method avoided the use of highly reactive molecules that decomposed in water, preventing amino acid self-reaction and enabling binding to RNA.

kathimerini.gr

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Jan 29, 22:11

Bennu Samples Reveal Building Blocks of Life and Early Solar System Water

NASA's OSIRIS-REx mission retrieved samples from near-Earth asteroid Bennu containing organic molecules, including amino acids and DNA/RNA nucleobases, and salts suggesting past water presence, offering insights into early solar system chemistry and prebiotic synthesis, as detailed in two Nature pub...

Bennu Samples Reveal Building Blocks of Life and Early Solar System Water

NASA's OSIRIS-REx mission retrieved samples from near-Earth asteroid Bennu containing organic molecules, including amino acids and DNA/RNA nucleobases, and salts suggesting past water presence, offering insights into early solar system chemistry and prebiotic synthesis, as detailed in two Nature pub...

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What is the significance of the salts found in the Bennu samples, and what does their presence suggest about the asteroid's history?

The Bennu samples, the first from an asteroid's surface obtained by NASA and the only ones collected from a planetary body in nearly 50 years, reveal thousands of organic molecules. These include 14 proteinogenic amino acids found in Earth life, 19 non-proteinogenic amino acids, and all five biological nucleobases. The asteroid's richness in nitrogen-containing compounds suggests formation in cold, outer solar system regions.

faz.net

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Jun 7, 19:10

SiRNA Therapy Shows Promise in Preventing Huntington's Disease

Anastasia Khvorova's research at UMass Chan Medical School developed biochemically stabilized siRNA molecules capable of suppressing fatal Huntington's RNA for up to a year after a single dose, potentially preventing disease onset, thus shifting the focus from treatment to prevention of Huntington's...

SiRNA Therapy Shows Promise in Preventing Huntington's Disease

Anastasia Khvorova's research at UMass Chan Medical School developed biochemically stabilized siRNA molecules capable of suppressing fatal Huntington's RNA for up to a year after a single dose, potentially preventing disease onset, thus shifting the focus from treatment to prevention of Huntington's...

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How will Khvorova's siRNA therapy change the prognosis and treatment approach for Huntington's disease, and what are the immediate implications for patients and families?

A groundbreaking discovery by Anastasia Khvorova may revolutionize Huntington's disease treatment. Khvorova's research at UMass Chan Medical School has yielded biochemically stabilized siRNA molecules that suppress the fatal Huntington's RNA for up to a year after a single dose. This could prevent the disease from ever manifesting, marking a shift from treatment to prevention.

mk.ru

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Jan 11, 19:09

ATXN2 Gene Defect Model Shows Promise for Neurodegenerative Disease Treatment

Russian scientists modeled an ATXN2 gene defect causing neurodegenerative diseases; abnormal CAG repeats disrupt protein synthesis, impacting nerve impulse transmission and correlating with disease onset age; future research will test drugs on mice to increase nuclear fluid viscosity.

ATXN2 Gene Defect Model Shows Promise for Neurodegenerative Disease Treatment

Russian scientists modeled an ATXN2 gene defect causing neurodegenerative diseases; abnormal CAG repeats disrupt protein synthesis, impacting nerve impulse transmission and correlating with disease onset age; future research will test drugs on mice to increase nuclear fluid viscosity.

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How does the length of the CAG tract in the ATXN2 gene affect the onset and severity of neurodegenerative diseases?

The SSC team's research reveals how the length of the CAG tract in the ATXN2 gene impacts disease onset. An increased number of repeats (e.g., 34, 50, or 70 instead of the normal 20) disrupts the gene's reading process, causing mismatches between gene fragments and protein components, similar to a broken zipper. This mismatch correlates with the age of disease onset; more repeats lead to earlier onset.

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