Tag #Xenotransplantation

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news.sky.com

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Mar 26, 19:24

World-First Pig-to-Human Liver Transplant Achieved in China

Surgeons in China successfully transplanted a genetically modified pig liver into a brain-dead human, marking a world-first in xenotransplantation; the liver functioned normally for 10 days before the family requested its removal.

World-First Pig-to-Human Liver Transplant Achieved in China

Surgeons in China successfully transplanted a genetically modified pig liver into a brain-dead human, marking a world-first in xenotransplantation; the liver functioned normally for 10 days before the family requested its removal.

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What are the immediate implications of the successful pig-to-human liver transplant in China for addressing global organ shortages?

The world's first pig-to-human liver transplant was successfully performed in China. The genetically modified pig liver functioned normally for 10 days in a brain-dead patient, producing bile and essential proteins before the family requested its removal. This is a significant advancement in xenotransplantation, potentially alleviating organ shortages.

welt.de

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Feb 18, 13:10

FDA Approves Pig Kidney Transplant Trials

The FDA approved clinical trials for pig kidney transplants in the US, offering hope for the thousands on organ waiting lists; researchers are genetically modifying pigs to prevent organ rejection, but challenges remain regarding infection risks and long-term outcomes.

FDA Approves Pig Kidney Transplant Trials

The FDA approved clinical trials for pig kidney transplants in the US, offering hope for the thousands on organ waiting lists; researchers are genetically modifying pigs to prevent organ rejection, but challenges remain regarding infection risks and long-term outcomes.

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How are researchers addressing the problem of immune rejection in xenotransplantation?

Genetic modification of pig organs is crucial to prevent immune rejection. Researchers, including those at TUM and LMU in Munich, are modifying pig cells' sugar structures to avoid triggering human antibodies. This approach shows promise, although the long-term survival rates of patients with animal organs remain significantly lower than those with human organs.

cnn.com

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Feb 8, 04:07

Successful Pig Kidney Transplant Offers Hope for Organ Failure Patients

66-year-old Tim Andrews, with end-stage kidney disease, received a successful pig kidney transplant at Massachusetts General Hospital on January 25, utilizing a genetically-modified organ from eGenesis via the FDA's Expanded Access pathway; this marks a major advancement in xenotransplantation, offe...

Successful Pig Kidney Transplant Offers Hope for Organ Failure Patients

66-year-old Tim Andrews, with end-stage kidney disease, received a successful pig kidney transplant at Massachusetts General Hospital on January 25, utilizing a genetically-modified organ from eGenesis via the FDA's Expanded Access pathway; this marks a major advancement in xenotransplantation, offe...

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How does the use of CRISPR gene editing technology contribute to the success and potential of xenotransplantation?

The successful pig-to-human kidney transplant in Tim Andrews highlights the potential of xenotransplantation to address the critical organ shortage. This innovative approach uses gene editing to overcome organ rejection and compatibility issues, offering hope for the 80,000-100,000 patients annually awaiting kidney transplants. The procedure's success, through the FDA's Expanded Access pathway, opens doors for broader clinical trials and transformative treatment options.

npr.org

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Jan 30, 19:11

Woman Thriving Two Months After World's First Successful Pig Kidney Transplant

Towana Looney, a 53-year-old woman from Alabama, is thriving two months after receiving the world's first successful genetically modified pig kidney transplant at NYU Langone Health, offering hope for addressing the critical organ shortage while raising ethical and scientific concerns.

Woman Thriving Two Months After World's First Successful Pig Kidney Transplant

Towana Looney, a 53-year-old woman from Alabama, is thriving two months after receiving the world's first successful genetically modified pig kidney transplant at NYU Langone Health, offering hope for addressing the critical organ shortage while raising ethical and scientific concerns.

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What are the immediate health implications of Towana Looney's genetically modified pig kidney transplant, and what does her case suggest about the future of xenotransplantation?

Towana Looney, 53, received the world's first genetically modified pig kidney transplant in late November and is thriving two months later, exceeding the survival time of four previous patients who received similar transplants. She reports significantly improved health, increased energy levels, and a return of her appetite, contrasting sharply with her previous struggles on dialysis.

apnews.com

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Jan 25, 19:09

Alabama Woman Sets Record with Successful Pig Kidney Transplant

An Alabama woman, Towana Looney, is thriving 61 days after receiving a genetically-modified pig kidney, setting a new record and providing crucial data for the field of xenotransplantation, addressing a critical shortage of human organs.

Alabama Woman Sets Record with Successful Pig Kidney Transplant

An Alabama woman, Towana Looney, is thriving 61 days after receiving a genetically-modified pig kidney, setting a new record and providing crucial data for the field of xenotransplantation, addressing a critical shortage of human organs.

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What is the immediate significance of Towana Looney's record-breaking pig kidney transplant success?

Towana Looney, a 53-year-old Alabama woman, has surpassed all previous records by living 61 days with a genetically-modified pig kidney transplant, exceeding the previous record of two months. Her kidney function is reported as "absolutely normal," offering significant hope for xenotransplantation.

europe.chinadaily.com.cn

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Jan 10, 04:06

World-First Pig Liver Transplant Achieves Success in China

In a world-first, doctors in Xi'an, China successfully transplanted a genetically modified pig liver into a brain-dead patient at Xijing Hospital, achieving stable vital signs and liver function, highlighting a potential solution to China's critical liver shortage affecting nearly 400 million people...

World-First Pig Liver Transplant Achieves Success in China

In a world-first, doctors in Xi'an, China successfully transplanted a genetically modified pig liver into a brain-dead patient at Xijing Hospital, achieving stable vital signs and liver function, highlighting a potential solution to China's critical liver shortage affecting nearly 400 million people...

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What challenges were overcome during the procedure, and how did the hospital ensure ethical compliance?

This successful xenotransplantation demonstrates the potential of using genetically modified pig livers as a viable alternative to human liver transplants. The procedure, adhering to international standards and ethical approvals, involved a complex process of pig liver excision, human liver removal, and implantation. This addresses China's critical need for liver transplants, where 300,000 to 500,000 new liver failure cases arise annually.

dailymail.co.uk

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Mar 26, 19:23

First Successful Pig-to-Human Liver Transplant

A team in China successfully transplanted a genetically modified pig liver into a 50-year-old brain-dead man, marking the first time a pig liver has been transplanted into a human and functioning for 10 days before the family terminated the experiment.

First Successful Pig-to-Human Liver Transplant

A team in China successfully transplanted a genetically modified pig liver into a 50-year-old brain-dead man, marking the first time a pig liver has been transplanted into a human and functioning for 10 days before the family terminated the experiment.

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What are the immediate implications of the successful pig-to-human liver transplant for patients with liver failure?

In a medical breakthrough, surgeons in China successfully transplanted a genetically modified pig liver into a deceased human recipient. The liver, sourced from a Bama miniature pig and modified to reduce rejection, functioned effectively for 10 days, producing bile and maintaining stable blood flow. This procedure, though terminated due to family request, showcases potential as a temporary bridge to human organ transplantation.

sueddeutsche.de

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Feb 14, 10:08

FDA Approves Pig Kidney Transplant Trials

The US FDA approved clinical trials for pig kidney transplants to combat the global organ shortage, with up to 50 patients participating in trials using genetically modified pig organs developed in the US and Europe; a recent case showed a 62-year-old lived nearly two months with a pig kidney before...

FDA Approves Pig Kidney Transplant Trials

The US FDA approved clinical trials for pig kidney transplants to combat the global organ shortage, with up to 50 patients participating in trials using genetically modified pig organs developed in the US and Europe; a recent case showed a 62-year-old lived nearly two months with a pig kidney before...

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What is the immediate impact of the FDA's authorization of clinical trials for pig kidney transplants?

The US Food and Drug Administration (FDA) recently authorized clinical trials for pig kidney transplants, marking a significant step in xenotransplantation. Up to 50 patients will participate in trials led by United Therapeutics and eGenesis, using genetically modified pig organs to address the critical organ shortage affecting over 8,000 people in Germany alone. This follows a case where a 62-year-old lived for nearly two months with a pig kidney.

npr.org

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Jan 31, 01:09

Alabama Grandmother Sets Record with Genetically Modified Pig Kidney

Towana Looney, an Alabama grandmother, has survived for over two months with a genetically modified pig kidney, exceeding previous records in xenotransplantation and offering hope for addressing the organ shortage; however, larger studies are needed to confirm long-term efficacy and address ethical ...

Alabama Grandmother Sets Record with Genetically Modified Pig Kidney

Towana Looney, an Alabama grandmother, has survived for over two months with a genetically modified pig kidney, exceeding previous records in xenotransplantation and offering hope for addressing the organ shortage; however, larger studies are needed to confirm long-term efficacy and address ethical ...

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What is the immediate significance of Towana Looney's extended survival with a pig kidney transplant?

Towana Looney, an Alabama grandmother, has surpassed all previous records by surviving for over two months with a genetically modified pig kidney transplant. This is a significant milestone in xenotransplantation research, offering hope for addressing organ shortages. Her improved health, including increased energy and appetite, showcases the potential benefits of this procedure.

cbsnews.com

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Jan 26, 01:05

Alabama Woman Thrives 61 Days After Historic Pig Kidney Transplant

Towana Looney, a 53-year-old from Alabama with high antibody levels, is thriving 61 days after receiving a genetically-modified pig kidney transplant, a major milestone advancing xenotransplantation research and offering hope to the over 100,000 people on the US transplant waiting list.

Alabama Woman Thrives 61 Days After Historic Pig Kidney Transplant

Towana Looney, a 53-year-old from Alabama with high antibody levels, is thriving 61 days after receiving a genetically-modified pig kidney transplant, a major milestone advancing xenotransplantation research and offering hope to the over 100,000 people on the US transplant waiting list.

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How did Looney's unique medical history (high antibody levels) influence the outcome and implications of her transplant?

Looney's case is particularly significant because she was highly sensitized, possessing high levels of antibodies that typically attack foreign organs. Her success challenges previous assumptions and provides invaluable data for upcoming formal studies on xenotransplantation, expected to begin this year. This success builds upon a 2023 experiment where a pig kidney functioned for 61 days in a deceased body.

news.sky.com

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Jan 25, 22:08

Longest-Surviving Pig Kidney Transplant Recipient Exceeds 61 Days

Towana Looney, 53, a US woman, has surpassed all previous records by surviving for 61 days with a genetically-modified pig kidney transplant after eight years on the transplant waiting list, providing hope for those awaiting organ donation.

Longest-Surviving Pig Kidney Transplant Recipient Exceeds 61 Days

Towana Looney, 53, a US woman, has surpassed all previous records by surviving for 61 days with a genetically-modified pig kidney transplant after eight years on the transplant waiting list, providing hope for those awaiting organ donation.

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What is the immediate significance of Towana Looney's successful pig kidney transplant?

Towana Looney, 53, holds the record as the longest-surviving recipient of a pig kidney transplant, exceeding 61 days post-surgery. She received the experimental transplant in November after years on the waiting list, and now reports feeling healthy and active, even exceeding family members in walks. This success is unprecedented, as previous recipients of gene-edited pig kidneys did not survive beyond two months.

es.euronews.com

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Dec 21, 13:08

US Companies to Begin Clinical Trials for Pig Organ Transplants in 2025

Facing a critical organ shortage, two US companies aim to start clinical trials in 2025 using genetically modified pig organs for transplantation, offering hope to patients like Alex Berrios who need transplants but lack compatible human donors.

US Companies to Begin Clinical Trials for Pig Organ Transplants in 2025

Facing a critical organ shortage, two US companies aim to start clinical trials in 2025 using genetically modified pig organs for transplantation, offering hope to patients like Alex Berrios who need transplants but lack compatible human donors.

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What is the impact of the critical organ shortage in the US on the development and interest in xenotransplantation?

The US is facing a critical shortage of transplantable organs, leading to increased interest in xenotransplantation, using genetically modified pig organs. Two US companies aim to begin clinical trials in 2025, focusing on kidneys and hearts. Patients like Alex Berrios, who needs a second transplant and faces compatibility issues, are eager for this alternative.

Showing 13 to 24 of 31 results