Tag #Stem Cells

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theglobeandmail.com

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Mar 9, 22:09

Gene Editing Offers Potential Cure for Newfoundland's 'Curse'

In Newfoundland, a genetic mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC), leading to sudden heart failure. Current treatment involves defibrillator implants, but researchers are using gene editing to correct the genetic defect in heart cells grown from patient samples, offer...

Gene Editing Offers Potential Cure for Newfoundland's 'Curse'

In Newfoundland, a genetic mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC), leading to sudden heart failure. Current treatment involves defibrillator implants, but researchers are using gene editing to correct the genetic defect in heart cells grown from patient samples, offer...

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What are the potential long-term impacts of successful gene editing on the healthcare costs and overall quality of life for ARVC patients and their families?

Successful gene editing in a petri dish could lead to treatments using stem cells from patients' own skin or direct genetic engineering to repair the heart's faulty gene. This could eliminate the need for defibrillators and prevent the severe consequences and costs associated with the disease, offering a significant improvement in the lives of those affected. The research's success would have a substantial impact on ARVC patients globally due to the widespread presence of this genetic mutation among various communities.

bbc.com

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Jan 29, 22:11

Lab-Grown Heart Patches Show Promise in Treating Advanced Heart Failure

German scientists report promising early results from a human trial of lab-grown heart muscle patches to treat advanced heart failure; a 46-year-old woman showed stable condition after receiving a patch before a heart transplant, offering hope for millions with limited treatment options.

Lab-Grown Heart Patches Show Promise in Treating Advanced Heart Failure

German scientists report promising early results from a human trial of lab-grown heart muscle patches to treat advanced heart failure; a 46-year-old woman showed stable condition after receiving a patch before a heart transplant, offering hope for millions with limited treatment options.

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What are the immediate implications of the successful human trial of lab-grown heart muscle patches for treating advanced heart failure?

Scientists in Germany have successfully tested lab-grown heart muscle patches in a small human trial, showing promise for treating advanced heart failure. One patient with severe heart failure received a patch and showed stable condition, with no adverse effects, before later receiving a heart transplant. The patches, grown from stem cells, are stitched onto the heart's surface to enhance pumping.

elmundo.es

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Jan 28, 19:13

Gene Editing Creates Adult Mice with Two Male Parents

A team of Chinese scientists created the first adult mice from two male parents via gene editing, modifying 20 imprinted genes to overcome previous developmental issues; while successful, only 11.8% of viable embryos reached adulthood and offspring were infertile.

Gene Editing Creates Adult Mice with Two Male Parents

A team of Chinese scientists created the first adult mice from two male parents via gene editing, modifying 20 imprinted genes to overcome previous developmental issues; while successful, only 11.8% of viable embryos reached adulthood and offspring were infertile.

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How did this research build upon previous attempts to create mice with two male parents, and what challenges remain before clinical application in humans?

The success builds on earlier research creating mice from two male parents, but this study addressed the developmental limitations. By targeting imprinted genes, researchers improved embryonic development and created adult mice, albeit with a low success rate (11.8% of viable embryos).

repubblica.it

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Jan 20, 16:10

AI Model GPT-4b Boosts Stem Cell Reprogramming Efficiency 50-fold

OpenAI and Retro Biosciences' AI model, GPT-4b, shows 50 times increased efficiency in applying Yamanaka factors for stem cell reprogramming, potentially revolutionizing regenerative medicine and extending human lifespan, though ethical considerations and peer review are necessary.

AI Model GPT-4b Boosts Stem Cell Reprogramming Efficiency 50-fold

OpenAI and Retro Biosciences' AI model, GPT-4b, shows 50 times increased efficiency in applying Yamanaka factors for stem cell reprogramming, potentially revolutionizing regenerative medicine and extending human lifespan, though ethical considerations and peer review are necessary.

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What role did Sam Altman's investment play in the development of GPT-4b and Retro Biosciences' broader mission to extend human lifespan?

This AI-driven approach builds upon Shinya Yamanaka's 2006 discovery of induced pluripotent stem cells (iPS). GPT-4b addresses limitations of this technique, namely the risk of genetic errors. By optimizing the process, the model aims to accelerate regenerative medicine advancements and enhance longevity.

smh.com.au

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Dec 11, 22:09

Australian Pet Stem Cell Bank Launches

Melbourne-based start-up Elita Genetics is launching Australia's first pet stem cell bank, addressing the $9 billion Australian pet healthcare market's growth with a service costing approximately $4500, including lifetime storage, for dogs and cats.

Australian Pet Stem Cell Bank Launches

Melbourne-based start-up Elita Genetics is launching Australia's first pet stem cell bank, addressing the $9 billion Australian pet healthcare market's growth with a service costing approximately $4500, including lifetime storage, for dogs and cats.

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What is the significance of Elita Genetics' pet stem cell bank for the Australian pet healthcare market?

Elita Genetics, a Melbourne-based start-up, is launching Australia's first pet stem cell bank. This $1 million venture will offer stem cell storage for dogs and cats, enabling future treatments for conditions like osteoarthritis. The service costs approximately $4500, including lifetime storage.

theguardian.com

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Jan 29, 19:11

Implantable Heart Patches Show Promise in Treating Advanced Heart Failure

German researchers have created implantable heart patches from reprogrammed cells that successfully improved heart function in monkeys and a human patient with advanced heart failure, offering a less invasive alternative to transplants and artificial pumps.

Implantable Heart Patches Show Promise in Treating Advanced Heart Failure

German researchers have created implantable heart patches from reprogrammed cells that successfully improved heart function in monkeys and a human patient with advanced heart failure, offering a less invasive alternative to transplants and artificial pumps.

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What are the key advantages of using donor cells to create the heart patches, compared to using a patient's own cells, and what are the potential risks and limitations?

The patches, composed of heart muscle and connective tissue cells embedded in a collagen gel, are created from donor cells to bypass the time and cost constraints of using a patient's own cells. Successful implantation in a 46-year-old woman and rhesus macaques demonstrated improved heart function and no adverse effects like tumor formation or irregular heartbeat, unlike direct cell injection.

pda.kp.ru

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Jan 29, 04:10

Personalized Cell Products Show Promise in Regenerating Damaged Tissues

Sechenov University scientists are developing personalized biomedicinal cell products (BMCPs) for regenerating vocal cords, eardrums, and nasal cavities; these "cocktails" of a patient's cells and medication promote faster, scar-free healing, with initial success shown in eardrum regeneration in ani...

Personalized Cell Products Show Promise in Regenerating Damaged Tissues

Sechenov University scientists are developing personalized biomedicinal cell products (BMCPs) for regenerating vocal cords, eardrums, and nasal cavities; these "cocktails" of a patient's cells and medication promote faster, scar-free healing, with initial success shown in eardrum regeneration in ani...

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What are the potential long-term implications of BMCP technology, and what future applications are under development?

Future applications of BMCPs extend beyond the current focus on vocal cords, eardrums, and nasal cavities. Research is underway to create BMCPs for repairing defects in the urinary tract, suggesting a wide range of potential future medical applications.

theglobeandmail.com

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Jan 28, 19:13

Genetically Engineered Mice with Two Male Parents Created

Chinese scientists genetically modified mouse embryonic stem cells to create bipaternal mice, achieving a low survival rate (12%) but opening possibilities for endangered species conservation and regenerative medicine.

Genetically Engineered Mice with Two Male Parents Created

Chinese scientists genetically modified mouse embryonic stem cells to create bipaternal mice, achieving a low survival rate (12%) but opening possibilities for endangered species conservation and regenerative medicine.

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How does this research advance the understanding of genomic imprinting and its role in mammalian reproduction?

The study targeted imprinted genes, believed to prevent unisexual reproduction in mammals. By modifying 20 of these genes and using cloning, the scientists produced bipaternal mice, demonstrating the potential to bypass the need for female gametes. The success rate was low (12%), and offspring exhibited developmental defects, highlighting challenges in this technique.

mk.ru

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Dec 18, 16:15

ISS Study Shows Accelerated Brain Cell Maturation in Microgravity

An ISS study revealed that brain cells matured faster in microgravity than on Earth, exhibiting less stress and inflammation; this suggests microgravity could provide a unique model for studying neurodegenerative diseases.

ISS Study Shows Accelerated Brain Cell Maturation in Microgravity

An ISS study revealed that brain cells matured faster in microgravity than on Earth, exhibiting less stress and inflammation; this suggests microgravity could provide a unique model for studying neurodegenerative diseases.

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What are the immediate implications of brain cells maturing faster in microgravity, as observed in the ISS study?

A study aboard the ISS revealed that brain cells not only survived but matured faster in microgravity than their Earth-based counterparts. This discovery, noted by molecular biologist Dr. Jayne Loring, could lead to experiments using brain parts affected by neurodegenerative diseases.

repubblica.it

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Nov 8, 19:15

Stem Cell Transplants Restore Vision

A study in The Lancet details successful stem cell transplants for treating corneal damage, leading to significant vision improvements in several patients.

Stem Cell Transplants Restore Vision

A study in The Lancet details successful stem cell transplants for treating corneal damage, leading to significant vision improvements in several patients.

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What are the next steps planned regarding this research?

The study, published in The Lancet, suggests that this approach to treating corneal damage holds great promise, and clinical trials are planned to further evaluate the treatment's effectiveness.

Showing 13 to 22 of 22 results